Rab GTPases and cell division
نویسندگان
چکیده
منابع مشابه
Rab GTPases coordinate endocytosis.
Endocytosis is characterized by vesicular transport along numerous pathways. Common steps in each pathway include membrane budding to form vesicles, transport to a particular destination, and ultimately docking and fusion with the target membrane. Specificity of vesicle targeting is rendered in part by associated Rab GTPases. This review summarizes current knowledge about Rab GTPase functions i...
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Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the prenylated protein to membranes. The REP-like protein Rab GDP dissociation inhibit...
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Rab proteins are a family of small GTPases which, since their initial identification in the late 1980s, have emerged as master regulators of all stages of intracellular trafficking processes in eukaryotic cells. Rabs cycle between distinct conformations that are dependent on their guanine-nucleotide-bound status. When active (GTP-bound), Rabs are distributed to the cytosolic face of specific me...
متن کاملRole of Rab GTPases in membrane traffic and cell physiology.
Intracellular membrane traffic defines a complex network of pathways that connects many of the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by its own set of factors, they all contain Rab GTPases that serve as master regulators. In this review, we discuss how Rabs can regulate virtually all steps of membrane traffic from the formation of the transport vesicle...
متن کاملRab GTPases at a glance.
There was an error published in J. Cell Sci. 120, 3905-3910. The authors regret that in Table 1 under ‘(13) Rab1, Rab3, Rab8, Rab10, Rab12, Rab13, Rab15, Rab35, Rab40’, Rab35 was incorrectly referred to as an uncharacterized member of the Rab family. The correct details are given below. Rab Localization Function Reference Rab35 Plasma membrane, endosomes, intercellular bridge Rapid endocytic re...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2017
ISSN: 2154-1248,2154-1256
DOI: 10.1080/21541248.2017.1313182